'Biological' depression; because sleep fails?

Hypothesis ' Biological ' depression ; because sleep fails ?

The melancholy mind has been recognized throughout recorded history. It was given a medical context by the ancient Greeks who claimed for it a relationship with constitution in the form of physique, body chemistry and temperament. It was subject to scholarly analysis by Burton (1927) over three hundred years ago. The disorder has not always been medicalized and some cultures have tended instead...

Sleep, Depression and Antidepressants

Bemmel, A.L. van and R.H. van den Hoofdakker. Maintenance of therapeutic effects of total sleepdeprivation by means of limitation of subsequent sleep. Abstr. 5th ESRS Congress, Amsterdam,1980.Smeets, E.H.J. and A.L. van Bemmel. Phase-advance of urinary MHPG excretion in normals anddepressives, Abstr. 11th CINP Congress, Florence, 1984.Bemmel, A.L. van, R. van Diest and J.H.M...

Sleep deprivation in depression.

Sleep deprivation (SD) is a powerful antidepressant treatment that shows antidepressant responses within hours in 40-60% of depressed patients. In more than 80% of responders to SD, a relapse into depression occurred after the recovery night. In addition, it serves as an excellent tool to examine the neurobiological disturbance of depression and may profoundly contribute to the development of n...

Immune surveillance against a solid tumor fails because of immunological ignorance.

Many peripheral solid tumors such as sarcomas and carcinomas express tumor-specific antigens that can serve as targets for immune effector T cells. Nevertheless, overall immune surveillance against such tumors seems relatively inefficient. We studied immune surveillance against a s.c. sarcoma expressing a characterized viral tumor antigen. Surprisingly, the tumor cells were capable of inducing ...

[Sleep and biological rhythms].